Master projects in signal transduction

We regularly take Masters-level students for research projects in the group and are always happy to hear from people who are interested in taking this route. Please contact Anja Thoe Fuglsang for further details ()

 

Recent master projects:

On the way to understand the signaling pathway leading to root elongation in A. thaliana that involves activation of the receptor PIRK by and extracellular ligand peptide (Astrid Kristensen, 2011)

 

In this project Astrid investigated the secretion of a peptide hormone PSY1 by generating GFP-fusion peptides expressed in tobacco and Arabidopsis. Further more the interaction of the peptide receptor and other proteins where investigated using the split-ubiquitin system and the split YFP (BiFC) system.

 

Yeast-two-hybrid screening for TIMP-1 interaction partners. (Mikkel Høeberg, 2010)

 

In this project Mikkel used the yeast two hybrid system to screen for proteins interacting with the TIPM-1 protein. To further understand the role of  TIMP-1 in relation to breast cancer a library where screened for TIMP-1 interacting proteins. A number of interesting clones where identified. The projects where performed in collaboration with Ulrik Lademann at Institute for Veterinary Pathobiolog.

 

Establisment of a heterologous G-protein coupled receptor pathway in S.cerevisiae, for detection of various olfactory receptor binding ligands (Iben Nordmark Støckler, 2010). In collaboration with Evolva A/S.

 

In this project Iben tried to establish a yeast screening system for detection of various olfactory receptor ligands.