P-type pumps: Structure, function and regulation

We are focused on studying P-type pump proteins in the biological membranes of higher plants. We are investigating the structure, function and regulation of pumps at the molecular, cellular and whole plant level. We use a combination of tools derived from molecular genetics, biochemistry, structural biology and physiology.

• Structure-function relationships in a P-type H⁺-pump
• The fungal plasma membrane H⁺-ATPase as an ideal antifungal target
• P5 ATPases: ubiquitous pumps having no assigned substrate
• Heavy metal pumps and epigenetic regulation of nutrient transport
  

Selected publications

Palmgren MG, Nissen P (2011) P-type ATPases. Annu Rev Biophys. 40: 243-66.

 

Morth JP, Pedersen BP, Buch-Pedersen MJ, Andersen JP, Vilsen B, Palmgren MG, Nissen P (2011) A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps. Nat Rev Mol Cell Biol. 12: 60-70.